난소절제로 유도된 골다공증 흰쥐에서 implant 주위 조직 반응에 관한 실험적 연구
EXPERIMENTAL STUDY OF PERI-IMPLANT TISSUE REACT10N IN OVARIECTOMIZED OSTEOPOROTIC RATS
조인호, 김종여, 박수성, 박종섭, 임헌송,
소속 상세정보
조인호 ( Cho In-Ho ) - 단국대학교 치과대학 치과보철학교실
김종여 ( Kim Jong-Yuh ) - 단국대학교 치과대학 구강해부학교실
박수성 ( Park Su-Seong ) - 단국대학교 치과대학 치과보철학교실
박종섭 ( Park Jong-Sup ) - 단국대학교 치과대학 구강해부학교실
임헌송 ( Lim Heon-Song ) - 단국대학교 치과대학 치과보철학교실
KMID : 0362419980360010183
Abstract
This study was designed to investigate the peri-implant tissue reaction in ovariectomized osteoporotic female rats, and to evaluate effects of estrogen, calcitonin, parathyroid hormone on the bone - implant interface in osteoporotic rats. 120 Sprague - Dawley rats were used in this experiments. Osteoporosis was induced by bilateral ovariectomy. They were divided 5 groups ; sham-operated control group(Sham), ovariectomized group (OVX), OVX and estrogen treated group (OVX+E), OVX and PTH treated group (OVX+PTH), and OVX and calcitonin treated group (OVX+CT). Eight weeks after ovariectomy, two titanium screw implants were inserted into the left tibia of each rat. Eight weeks after the insertion of the implants, the periotest values (PTV) of implant were examined, and the rats were sacrificed, and examined the reaction of bone tissue surrounding the implant both histologically and histomorphometrically. The bone density and ash weight of opposite right tibia were examined. Over 40 rats were fractured on left tibia that was implant inserted. On histologically finding, all groups were osseointegrated well, especially in OVX+PTH group. In OVX group, tibial cortical bone showed many large harversian canal and microfracture lines. The OVX+PTH group showed the lowest mean PTV (-2.33) (p<0.05), and the hightest mean bone - implant contact percentage (89%) (p>0.05). But the OVX+CT group showed the highest mean bone density (5.45mg/cm3) and ash weight (56.12%) (p<0.05). The results indicate that PTH treatment enhances osseointegration of implant in OVX rats, and CT treatment depresses bone turnover and prevent the development of osteopenia in OVX rats.
키워드
Calcitonin; Estrogen; Osteoporosis; Ovariectomy(OVX); PTH; Titanium Implant
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